CRF Manager
Helen Radford is the CRF Manager at Leeds Teaching Hospitals NHS Trust (LTHT) and Honorary Clinical Associate Professor at the Leeds Institute of Clinical Trials Research, University of Leeds. Helen is a Registered General Nurse with over 20 years’ experience in designing, conducting and delivering academic and commercial clinical research studies.
Helen has held clinical research positions in the NHS (Research Nurse, Clinical Trials Manager, Operational & Scientific Manager and Director of Operations), Industry (Senior Project Manager Phase I-IIA) and Higher Educational Institutes (Project Manager/Lead Nurse). In the NHS, Helen has extensive experience in clinical drug development studies (Phase I-IV: First in Human, proof of concept, singular and multiple ascending dose designs), interventional medical devices and observational studies (Phase II-IV) and co-developed the first research delivery teams at St Gemma’s Hospice and Pain Management Services at LTHT. Helen has clinical research experience in oncology, palliative care, diabetes, musculoskeletal diseases, neurosurgery, neurology, pain management, renal medicine and infection.
In 2015, Helen completed her Biomedical Science PhD which investigated individual’s clinical response to codeine, an analgesic drug which is reliant on bio-transformation by the CYP2D6 enzyme to the active compound morphine for analgesic efficacy. Through a series of research studies, she developed a biomedical model to predict long term codeine response using genotyping and measuring codeine metabolites in urine to enable healthcare professionals to objectively assess CYP2D6 function at the point of care and in essence provide a personalised treatment plan.
Helen has experience serving in national and regional groups relating to healthcare research. She is a manuscript reviewer for Neuromodulation: Technology at the Neural Interface, the official journal of the International Neuromodulation Society. Her research collaborations have resulted in 14 co-authored publications disseminating independent research in leading professional journals plus she has presented 12 abstracts at national and international conferences.