The St James’s (SJUH) CRF is our largest facility, which has the capabilities and staff expertise to deliver first-in-human trials and Advanced Therapy trials in a range of diseases. Established 2011 and relocated in February 2020 to a larger, purpose built, state-of-the-art facility supporting day-care, outpatient clinics and overnight stays. The CRF is located adjacent to the solid tumour and haemato-oncology services, including the Teenage and Young Adult Unit, with easy access to:
• High Dependency Unit (HDU)/Intensive Care Units (ICU): 24/7 specialist critical care outreach (transfer time <5 minutes).
• North East and Yorkshire Genomic Laboratory Hub : Molecular genetics/cytogenetics/molecular oncology diagnostic facility; UK Genetic Testing Network Member; UKAS accredited.
• Radiology Department: Research dedicated cross sectional (CT/MRI) and functional (PET/CT) imaging facility; interventional suite (CT/US guided biopsy drug delivery).
• Clinical Trials Pharmacy: 24/7 research dispensary/aseptic suite/biotherapy suite/ radiopharmacy.
• CR UK RadNet Centre and Radiotherapy Department with 12 external beam linacs/gamma knife/brachytherapy suite; MRI simulator (operational 2022).
• Leeds Biobanking and Sample Processing Laboratory : Complex sampling; BioBanking; Confederation of Cancer Biobanks Member.
• Paroxysmal Nocturnal Haemoglobinuria National Service : led by Leeds with London, providing world-leading clinical expertise and education.
• Haematology Malignancy Diagnostics Service : UK’s premier diagnostic/biomarker haemato-pathology unit; regional/national/international central laboratory for haematology trials; UKAS accredited.
• Yorkshire Blood and Bone Marrow Transplant and Cellular Therapy Services : Quaternary referral transplantation centre; full CAR-T delivery accreditation.
• Therapeutic Apheresis Unit (NHS Blood and Transplant): Accredited for Wave 2 CAR-T/ Immune Effector Cell therapy.
• Leeds Teaching Hospitals Pathology Department[HR8] : Clinical Genetics (including research),Microbiology, Cellular Pathology, Blood Transfusion Services, Blood Sciences, Digital Pathology, Genetics Lab, Specialist Laboratory Medicine (SLM), Solid Malignancy Diagnostic Service (SMDS).
• SJUH Patient Hotel : 20 rooms for self-caring patients, not needing monitoring.
Onsite Clinical Resources:
• 18 treatment beds/chairs, 2 en-suite single rooms.
• Four outpatient rooms; consulting/examination areas.
• Multifunctional procedure/treatment room: LED Surgical Light System, supports endoscopies and bone marrow/skin biopsies.
• Two purpose-built Good Clinical Laboratory Practice laboratories:
- Laboratory Freezers: -80oC x 3, -20oC x 3 (monitored 24/7 by CheckIT automated monitoring)
- Laboratory Sample Fridge x 4 (monitored 24/7 by CheckIT automated monitoring)
- Bench Top Refrigerated Centrifuge: Up to 16,000 rpm (fixed and swing angle) x 7
- Bench Top Ambient Centrifuge: Up to 4,000 rpm (fixed and swing angle) x 1
- Class II Biological Safety Cabinet: Suitable for use with class I, II or III organisms with appropriate risk assessment, annually calibrated to national standards
• Portable Vital Signs Monitors (17), Emergency Resuscitation Trolley (2), Urine Analyser Machine (1), 12 Lead Portable ECG Machine (2), Blood Glucose Monitor (1), Volumetric Infusion Pumps (17), Audio Visual Facilities,
• Reception/waiting area.
• Conference/meeting room.
• Office.